Human pTau181 Antibody Pair(ARA972/ARA975)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:pTau181
-
Brand:
CAT.NO. : ARA6853
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Plasma phosphorylated tau 181 (p-tau181) has emerged as a promising biomarker for Alzheimer's disease (AD) and related conditions. Studies show that elevated plasma p-tau181 levels are associated with increased amyloid-beta (Aβ) deposits across various brain regions in cognitively healthy adults. Furthermore, p-tau181 levels correlate with Aβ-positivity on positron emission tomography (PET), and they predict the conversion to dementia stage depending on renal function. However, p-tau181 does not appear to be directly linked to tau-PET burden.Additionally, plasma p-tau181 levels have been associated with cognitive decline in various populations, such as those with AD, mild cognitive impairment (MCI), and other neurodegenerative diseases. Moreover, p-tau181 levels have been identified as a noninvasive diagnostic and prognostic tool in clinical practice and trials.
Application
The pTau181 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| pTau181 Antibody | ARA6838 | Mouse IgG1 | 100μg | Liquid |
| Tau Antibody | ARA6841 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human p-Tau181 Protein | AXP6613 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
pTau181 |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human p-Tau181 Protein |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT; UniProt Accession: P10636-8; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6838 at 1 µg/mL as the capture antibody. Recombinant pTau181 protein (Cat #: AXP6613) was used as the antigen. 100 ng/mL biotin conjugated Tau Antibody (ARA6841) was used as the detection antibody.
Result: ARA6838 and ARA6841 can be used as a matched antibody pair to detect and quantify the concentration of Human pTau181 with high specificity.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
