Human pTau217 Antibody Pair(ARA980/ARA958)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:pTau217
-
Brand:
CAT.NO. : ARA6854
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Size:
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Product Details
Background
Plasma p-tau217 is a biomarker associated with Alzheimer's disease (AD) pathology. Research has shown that plasma p-tau217 is a sensitive marker of the clinical manifestation and progression of AD, including amyloid accumulation, tau burden, brain atrophy, and physical degradation. It has been found to be a potential non-invasive biomarker of AD, with high diagnostic accuracy in differentiating AD from other neurodegenerative diseases. Plasma p-tau217 has also been associated with longitudinal increases in Aβ PET uptake and cognitive decline in Aβ-positive clinically unimpaired individuals. Additionally, higher baseline p-tau217 levels have been linked to greater future tau PET pathology burden and worse future memory performance. These findings suggest that plasma p-tau217 could serve as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials.
Application
The pTau181 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| pTau217 Antibody | ARA6846 | Mouse IgG1 | 100μg | Liquid |
| Tau Antibody | ARA6807 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human p-Tau217 Protein | AXP6612 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
pTau217 |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human p-Tau217 Protein |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT; UniProt Accession: P10636-8; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6846 at 4 µg/mL as the capture antibody. Recombinant pTau217 protein (Cat #: AXP6612) was used as the antigen. 30 ng/mL biotin conjugated Tau Antibody (ARA6807) was used as the detection antibody.
Result: ARA6846 and ARA6807 can be used as a matched antibody pair to detect and quantify the concentration of Human pTau217 with high specificity.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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