Human pTau231 Antibody Pair(ARA973/ARA958)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:pTau231
-
Brand:
CAT.NO. : ARA6856
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
p-Tau231 is a biomarker used to detect incipient Alzheimer's disease pathology. It is a phosphorylated form of tau protein, which is primarily localized in neurons of the central nervous system and is involved in microtubule stabilization. Tau elevation is observed in the cerebrospinal fluid (CSF) of patients with neurodegenerative disease and severe head injuries, suggesting its extracellular release during neuronal damage and a role as a biomarker with specificity for brain injury. In Alzheimer's disease and related neurodegenerative diseases, including chronic traumatic encephalopathy, tau is abnormally phosphorylated and aggregated into bundles of filaments. P-Tau231 has been shown to differentiate Alzheimer's disease from healthy controls and can identify patients with AD and differentiate them from amyloid-β negative cognitively unimpaired older adults. It is a promising novel biomarker of emerging AD pathology with the potential to facilitate clinical trials.
Application
The pTau231 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| pTau231 Antibody | ARA6839 | Mouse IgM | 100μg | Liquid |
| Tau Antibody | ARA6807 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human p-Tau231 Protein | AXP6614 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
pTau231 |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human p-Tau231 Protein |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT; UniProt Accession: P10636-8; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6839 at 2 µg/mL as the capture antibody. Recombinant pTau231 protein (Cat #: AXP6614) was used as the antigen. 100 ng/mL biotin conjugated Tau Antibody (ARA6807) was used as the detection antibody.
Result: ARA6839 and ARA6807 can be used as a matched antibody pair to detect and quantify the concentration of Human pTau231 with high specificity.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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