anti-CD172a / SIRP alpha antibody [OX-41] (Biotin)
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Key features and details
- 产品描述:
- 反应物种:
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- 克隆:
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- 同位型:
- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG22568
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Product Details
概述
| 产品描述 | Biotin-conjugated Mouse Monoclonal antibody [OX-41] recognizes CD172a / SIRP alpha. This antibody recognizes rat CD172a, also known as Signal regulatory protein (SIRP). CD172a is expressed selectively by myeloid cells and by neurons.MRC OX-41 binds to a different epitope on SIRP than ED9. It does not block the interaction of CD172a - CD47. |
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| 反应物种 | Rat |
| 应用 | FACS, IHC-Fr, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | OX-41 |
| 同位型 | IgG2a |
| 靶点名称 | CD172a / SIRP alpha |
| 抗原物种 | Rat |
| 抗原 | Rat peritoneal macrophages. |
| 偶联标记 | Biotin |
| 別名 | CD172A; p84; SHPS1; SHPS-1; CD172 antigen-like family member A; Sirp-alpha-3; Sirp-alpha-1; BIT; MYD-1; MFR; Bit; PTPNS1; CD antigen CD172a; Inhibitory receptor SHPS-1; SIRP; MyD-1 antigen; Sirp-alpha-2; Tyrosine-protein phosphatase non-receptor type substrate 1; Signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; Macrophage fusion receptor; Brain Ig-like molecule with tyrosine-based activation motifs; P84; SHP substrate 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase. FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS, 0.09% Sodium azide and 1.0% BSA. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 1.0% BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P97710 Rat Tyrosine-protein phosphatase non-receptor type substrate 1 |
|---|---|
| 基因名称 | Sirpa |
| 全名 | signal-regulatory protein alpha |
| 背景介绍 | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Neuroscience antibody; Cardiomyocyte Cell Surface Marker antibody |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. [UniProt] |
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