anti-CD2 antibody [LT2] (PE)
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Key features and details
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [LT2] recognizes CD2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone LT2 reacts with CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes. HLDA VI; WS Code T 6T-008 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | LT2 |
| 同位型 | IgG2b |
| 靶点名称 | CD2 |
| 抗原物种 | Human |
| 抗原 | Normal human blood lymphocytes. |
| 偶联标记 | PE |
| 別名 | T-cell surface antigen T11/Leu-5; LFA-3 receptor; T-cell surface antigen CD2; SRBC; Erythrocyte receptor; CD antigen CD2; T11; Rosette receptor; LFA-2 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | CD2 |
| 全名 | CD2 molecule |
| 背景介绍 | CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. |
| 生物功能 | CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 39 kDa |
ARG53789 anti-CD2 antibody [LT2] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG53789 anti-CD2 antibody [LT2] (PE) (20 µl reagent / 100 µl of peripheral whole blood).
ARG53789 anti-CD2 antibody [LT2] (PE) FACS image
Flow Cytometry: Separation of human CD2 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed). Human peripheral whole blood stained with ARG53789 anti-CD2 antibody [LT2] (PE) (20 µl reagent / 100 µl of peripheral whole blood).
克隆号文献
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features.
[A panel of monoclonal antibodies against human lymphocyte antigens].
Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen.
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