anti-EpCAM antibody [VU-1D9] (PE)
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Key features and details
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [VU-1D9] recognizes CD326 / EpCAM |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone VU-1D9 recognizes an epitope within EGF-like domain I of CD326 / EpCAM, a marker of epithelial lineages. This antibody strongly stains various normal epithelial cells and carcinomas. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | VU-1D9 |
| 同位型 | IgG1 |
| 靶点名称 | EpCAM |
| 抗原 | Small cell lung carcinoma cell line H69. |
| 偶联标记 | PE |
| 別名 | MIC18; EGP; Tumor-associated calcium signal transducer 1; Epithelial glycoprotein 314; KSA; Ep-CAM; Epithelial cell surface antigen; Adenocarcinoma-associated antigen; HNPCC8; Cell surface glycoprotein Trop-1; EGP40; TACSTD1; KS1/4; hEGP314; Major gastrointestinal tumor-associated protein GA733-2; M4S1; MK-1; Epithelial glycoprotein; KS 1/4 antigen; ESA; DIAR5; EGP314; Epithelial cell adhesion molecule; EGP-2; TROP1; CD antigen CD326 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
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| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
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| 基因名称 | EPCAM |
| 全名 | epithelial cell adhesion molecule |
| 背景介绍 | EpCAM is a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008] |
| 生物功能 | EpCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. [UniProt] |
| 研究领域 | Controls and Markers antibody; Epithelial Marker antibody; Circulating Tumor Cells BioMarker antibody |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
ARG53829 anti-EpCAM antibody [VU-1D9] (PE) FACS image
Flow Cytometry: MCF-7 cells stained with ARG53829 anti-EpCAM antibody [VU-1D9] (PE).
克隆号文献
Superficial scrapings from breast tumors is a source for biobanking and research purposes.
Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential.
FACS / Human
Differential gene expression in normal esophagus and Barrett's esophagus.
IHC / Human
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.
IHC / Human
EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder.
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential.
IHC / Human
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