anti-Histone H2B acetyl (Lys11) antibody [RM456]
![anti-Histone H2B acetyl (Lys11) antibody [RM456]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
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- 靶点名称:
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Brand:
CAT.NO. : ARG45028
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Product Details
概述
| 产品描述 | Rabbit monoclonal antibody recognizes Histone H2B acetyl (Lys11). |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 特异性 | This antibody reacts to Histone H2B acetylated at Lysine 11 (K11ac). No cross reactivity with other acetylated Lysines in histones. |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | RM456 |
| 同位型 | IgG |
| 靶点名称 | Histone H2B |
| 抗原物种 | Human |
| 抗原 | An acetyl-peptide corresponding to Acetyl-Histone H2B (Lys11). |
| 偶联标记 | Un-conjugated |
| 別名 | H2BC4; H2B Clustered Histone 4; H2B/L; HIST1H2BC; H2B.1; H2BFL; Histone Cluster 1 H2B Family Member C; H2B Histone Family, Member L; Histone H2B Type 1-C/E/F/G/I; Histone Cluster 1, H2bc; Histone 1, H2bc; Histone H2B.1 A; Histone H2B.L; Histone H2B.A; Histone H2B.G; Histone H2B.H; Histone H2B.K; DJ221C16.3; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI; H2BC10; H2BC6; H2BC7; H2BC8; H2BFH; H2BFG; H2BFA; H2BFK; H2B/A; H2B/G; H2B/H; H2B/K |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 稳定剂 | 50% Glycerol, 1% BSA and 0.09% |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 基因名称 | H2BC4 |
|---|---|
| 全名 | H2B Clustered Histone 4 |
| 背景介绍 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Apr 2020] |
| 生物功能 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. [Uniprot] |
| 细胞定位 | Chromosome, Nucleosome core, Nucleus. [Uniprot] |
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