anti-iNOS antibody [SP126]

Key features and details

产品描述: Rabbit Monoclonal antibody [SP126] recognizes iNOS
反应物种: Hu
预测物种: Ms, Rat
应用: IHC-P
宿主: Rabbit
克隆: Monoclonal
克隆号: SP126
同位型: IgG
靶点名称: iNOS

Brand:

CAT.NO. : ARG53372

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Size:

100 μl

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*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rabbit Monoclonal antibody [SP126] recognizes iNOS
反应物种	Hu
预测物种	Ms, Rat
应用	IHC-P
宿主	Rabbit
克隆	Monoclonal
克隆号	SP126
同位型	IgG
靶点名称	iNOS
抗原物种	Human
抗原	Synthetic peptide near the C-terminus of mouse iNOS protein.
偶联标记	Un-conjugated
別名	HEP-NOS; Inducible NO synthase; INOS; Nitric oxide synthase, inducible; iNOS; Hepatocyte NOS; NOS2A; Peptidyl-cysteine S-nitrosylase NOS2; Inducible NOS; NOS; NOS type II; EC 1.14.13.39

应用说明

应用建议

应用	推荐稀释比
IHC-P	1:100

应用说明

IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Lung

属性

形式	Liquid
纯化	Purified by protein A/G
缓冲液	PBS (pH 7.6), 1% BSA and
抗菌剂
稳定剂	1% BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 4843 Human NOS2 Swiss-port # P35228 Human Nitric oxide synthase, inducible
基因名称	NOS2
全名	nitric oxide synthase 2, inducible
背景介绍	iNOS: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide synthase is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
生物功能	iNOS produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). [UniProt]
细胞定位	Cytoplasm
产品亮点	Related products: iNOS antibodies; iNOS ELISA Kits; iNOS Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Tumor-Infiltrating Lymphocytes (TILs) New antibody panels and duos for Tumor immune microenvironment Exploring Antiviral Immune Response Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH
研究领域	Inflammation Study antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody
预测分子量	131 kDa

检测图片 (2)

ARG53372 anti-Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] IHC-P image
Immunohistochemistry: Human Lung stained with Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] (ARG53372)
ARG53372 anti-Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] IHC-P image
Immunohistochemistry: Human Lung stained with Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] (ARG53372)