anti-MC1R antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57965
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MC1R |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MC1R |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to a sequence within aa. 200 to the C-terminus of Human MC1R (NP_002377.4). |
| 偶联标记 | Un-conjugated |
| 別名 | SHEP2; MSH-R; Melanocyte-stimulating hormone receptor; CMM5; MC1-R; Melanocortin receptor 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa | ||||
| 实际分子量 | 36 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q01726 Human Melanocyte-stimulating hormone receptor Swiss-port # Q01727 Mouse Melanocyte-stimulating hormone receptor |
|---|---|
| 基因名称 | MC1R |
| 全名 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
| 背景介绍 | This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. [UniProt] |
| 细胞定位 | Cell membrane, Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 35 kDa |
检测图片 (1)
ARG57965 anti-MC1R antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG57965 anti-MC1R antibody at 1:3000 dilution.
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