Beta-Catenin Rabbit Monoclonal Antibody(ARB882)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6674
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Product Details
Background
Beta-Catenin is a key regulatory protein in Wnt signaling, a pathway that transmits signals from the cytoplasm to the nucleus, turning on the expression of specific genes in the nucleus.Under normal conditions, Beta-Catenin exists mainly in the cell membrane of normal cells, and gene mutations lead to accumulation in the nucleus. At present, Beta-Catenin gene mutation has been found in various tumors, such as colon cancer, lung cancer, prostate cancer, esophageal cancer, breast cancer, ovarian cancer, endometrial cancer, familial adenomatous polyposis, solid pseudopapilloma of pancreas, etc. High levels of nucleus positivity are seen in desmoid fibromatosis, isolated fibrous tumors, synovial sarcomas and endometrial stromal sarcomas, and carcinosarcomas. It is mainly used for the diagnosis, invasion and metastasis of malignant tumor.
Overview
| Target | Beta-Catenin |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 86 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P35222 |
| Immunogen | Synthetic peptide corresponding to Human Beta-Catenin |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane, Cytoplasm & Nucleus |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human breast carcinoma tissue sections using Beta-Catenin Rabbit Monoclonal Antibody (ARB882).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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