CD123 Mouse Monoclonal Antibody(ARM588)

Key features and details

Reactivity:Human
Application:IHC
Host:Mouse
Clonality:Monoclonal
lsotype:IgG1
Target Name:CD123

Brand:

CAT.NO. : ARM6878

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Size:

1mL

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Product Details

Background

Cluster of Differentiation 123 (CD123), also known as Interleukin-3 Receptor, plays an important role in regulating the immune system by transmitting interleukin-3 signals, thereby promoting proliferation and differentiation of hematopoietic stem cells. Studies suggest that the expression of CD123 is observed in most Acute Myeloid Leukemia (AML) subtypes, including leukemic stem cells. CD123 positive AML has demonstrated higher marrow blast percentages and monocytic differentiation, and clinical presentations for AML mostly include bone marrow involvement and regional lymphadenopathy. As there are overlapping clinical presentations between AML and blastic NK-cell lymphomas, differential diagnosis is important; use of a panel of CD123, CD4, CD56, and TCL-1 can help with this distinguishment between AML and myeloid involvement from blastic NK-cell lymphomas.

Application

Application	Dilution Ratio
IHC	1:50-1:200

Overview

Molecular Weight	34,466 Da
OMIM	gene 430000
3D Structure	ModBase 3D Structure for P26951
Clonality	Monoclonal
Isotype	IgG1
Host	Mouse
Species Reactivity	Human
Specificity	CD123
Purity/Purification	Purified
Form/Format	Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Immunogen	Recombinant Protein