CD51 Rabbit Monoclonal Antibody(ARA877)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB
- Host:Rabbit
- Clonality:Monoclonal
- Target:CD51
-
Brand:
CAT.NO. : ARA6704
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Product Details
Background
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:1000 |
Overview
|
Immunogen |
KLH-conjugated synthetic peptide encompassing a sequence within human CD51 protein. The exact sequence is proprietary |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography |
|
Clonality |
Monoclonal |
|
Form |
Liquid in PBS, pH 7.4, containing 50% glycerol, 0.2% BSA and 0.01% sodium azide |
|
Gene Name |
ITGAV |
|
Synonyms |
MSK3; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD51 |
|
Gene ID (Human) |
3685 |
|
Gene ID (Mouse) |
16410 |
|
Protein ID (Human) |
P06756 |
|
Protein ID (Mouse) |
P43406 |
Data
Western blot analysis of CD51 expression in K562 (A), A375 (B), mouse liver (C), mouse kidney (D), rat liver (E), rat kidney (F) whole cell lysates. (Predicted band size: 116 kD; Observed band size: 125 kD)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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