CD63 Rabbit Monoclonal Antibody(ARB912)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6704
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Size:
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Product Details
Background
CD63 Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. It plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. It promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration. It also plays a role in intracellular vesicular transport processes. CD63 is weakly expressed on B and T cells and granulocytes. It’s also expressed in bronchial glands, neural tissue (brain white matter and peripheral nerves), nevi, salivary glands, smooth muscle and synovial lining cells. CD63 is a marker of melanoma (although non-specific) and melanocytic tumors.
Applicationiew
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 26kDa |
| Species Cross-reactivity | Human |
| Applications | IHC-P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P08962 |
| Subcellular location | Membrane and cytoplasm |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
Immunohistochemical staining of human malignant melanoma tissue using CD63 Rabbit Monoclonal Antibody (ARB912).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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