Claudin 7 Mouse Monoclonal Antibody(ARA853)

Key features and details

Reactivity:Human, Mouse, Rat
Application:IHC
Host:Mouse
Clonality:Monoclonal
Target:Claudin 7

Brand:

CAT.NO. : ARA6679

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Size:

1mL

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Product Details

Background

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells. It is expressed in kidney, lung and prostate. Claudin-7 is down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

Application

Application	Dilution Ratio
IHC-P	1:1000 - 1:5000

Overview

Antibody Type	Recombinant Mouse Monoclonal Antibody
Immunogen	Synthetic peptide within Human Claudin 7 aa 162 - 211 / 211
Species Reactivity	Human, Mouse, Rat
Molecular Weight	Predicted band size: 22 kDa
Positive Control	SW480 cell lysate, MCF7 cell lysate, LNCaP cell lysate, Caco - 2 cell lysate, A431 cell lysate, mouse colon tissue lysate, rat colon tissue lysate, PC - 12, human kidney tissue, human colon tissue, mouse colon tissue, rat colon tissue
Conjugation	unconjugated
Form	Liquid
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG1
Purification Method	Protein A affinity purified