Gephyrin Mouse Monoclonal Antibody (45)
Key features and details
- Reactivity:Human, Mouse, Rat, Drosophila
- Application:WB, IP, IF, IHC(P)
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1
- Target:Gephyrin
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Brand:
CAT.NO. : ARA0045
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Size:
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Product Details
Background
The sub - membraneous region at the postsynaptic membrane contains a number of proteins critical for receptor targeting. Gephyrin is a microtubule - associated protein highly expressed in brain and localized to neuronal postsynaptic membranes. Gephyrin is essential for the postsynaptic localization of the inhibitory Glycine receptor and is thought to anchor the receptor to subsynaptic microtubules. The protein is expressed in most mammalian tissues with predominant expression in brain. At least five additional splice variants of Gephyrin ranging in molecular weight have been identified in rat and human brain tissue.
Application
Gephyrin (45) is recommended for detection of Gephyrin of mouse, rat, human and Drosophila melanogaster origin by Western Blotting (starting dilution 1:200, dilution range 1:100 - 1:1000), immunoprecipitation [1 - 2 µg per 100 - 500 µg of total protein (1 ml of cell lysate)], immunofluorescence (starting dilution 1:50, dilution range 1:50 - 1:500) and immunohistochemistry (including paraffin - embedded sections) (starting dilution 1:50, dilution range 1:50 - 1:500).
Data
Gephyrin (45). Western blot analysis of Gephyrin expression in rat brain tissue extract.
Gephyrin (45). Immunoperoxidase staining of formalin - fixed, paraffin - embedded rat cerebellum tissue showing cytoplasmic staining.
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