Helicobactor pylori Rabbit Monoclonal Antibody(ARB587)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:Helicobactor pylori

Brand:

CAT.NO. : ARB6879

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Size:

1mL

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Product Details

Background

Helicobacter pylori is a spiral-shaped, microaerophilic, Gram-negative bacterium that colonizes the human gastric mucosa, utilizing polar flagella for motility and adhering to epithelial cells via adhesins (e.g., BabA, SabA). Its primary biological functions center on surviving the acidic gastric environment through urease activity, which hydrolyzes urea into ammonia and bicarbonate to neutralize stomach acid, establishing a niche for chronic persistence. The detection of Helicobacter pylori in clinical pathology specimens, primarily through histological examination of gastric biopsies (using stains such as Giemsa, Warthin-Starry or immunohistochemistry), provides critical diagnostic information. This is achieved by directly confirming active infection and visually correlating the bacteria's presence with the type and severity of associated mucosal damage, including chronic active gastritis, glandular atrophy, intestinal metaplasia and mucosal lymphoid follicles.

Application

Application	Dilution Ratio
IHC-P	1:100-1:200

Overview

Species Cross-reactivity	Helicobacter pylori
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Subcellular location	Positive overall cytoplasm of Helicobacter pylori (gastric mucosal epithelium)
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes.
Immunogen	Tissue, cells or virus.
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%