Human ARG1(Arginase-1) ELISA Kit

Key features and details

Sensitivity:1.875ng/ml
Detection Range: 3.125 - 200ng/ml
Sample Types: Serum, Plasma, Cell culture supernatant, Cell lysate or tissue lysate, Other biological fluid samples
Species:Universal
Detection Method: Sandwich ELISA, Double Antibody
Target:ARG1(Arginase-1)

Brand:

CAT.NO. : ARE6621

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Size:

96T

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Product Details

Background

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Overview

Species	Human
UniProt ID	Q16236
Sample Types	Serum, Plasma, Cell culture supernatant, Cell lysate or tissue lysate, Other biological fluid samples
Detection Method	Sandwich ELISA, Double Antibody
Detection Wavelength	OD450
Reaction Time	4 hours
Detection Range	0.156 - 10ng/ml
Sensitivity	0.094ng/ml
Specificity	Specifically binds to NFE2L2, no obvious cross - reaction with other analogs