Human BD-4 / beta Defensin-4 ELISA kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG80902
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Product Details
概述
| 产品描述 | ARG80902 Human BD-4 / beta Defensin-4 ELISA kit is a Enzyme Immunoassay kit for the quantification of Human BD-4 / beta Defensin-4 in Serum, Plasma, Cell culture supernatants |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | No significant cross-reactivity or interference with BD-1 (36 aa), BD-1 (47 aa), BD-2, BD-3. |
| 靶点名称 | BD4 / beta Defensin 4 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm |
| 灵敏度 | 0.8 pg/ml |
| 样品类型 | Serum, Plasma, Cell culture supernatants |
| 标准范围 | 1.56 - 100 pg/ml |
| 样本量 | 100 µl |
| 精确 | CV: less than10% |
| 別名 | DEFB-4; hBD-4; Defensin, beta 104; Beta-defensin 104; DEFB4; BD-4; Beta-defensin 4; DEFB104 |
应用说明
| 检测时间 | 4 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DEFB104A |
| 全名 | defensin, beta 104A |
| 背景介绍 | Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses [PMID: 8528769], containing three pairs of intramolecular disulphide bonds. On the basis of their size and pattern of disulphide bonding, mammalian defensins are classified into alpha, beta and theta categories. Every mammalian species explored thus far has beta-defensins. In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs (e.g. the epidermis, bronchial tree and genitourinary tract). Defensins are produced constitutively and/or in response to microbial products or proinflammatory cytokines. Some defensins are also called corticostatins (CS) because they inhibit corticotropin-stimulated corticosteroid production. The mechanism(s) by which microorganisms are killed and/or inactivated by defensins is not understood completely. However, it is generally believed that killing is a consequence of disruption of the microbial membrane. The polar topology of defensins, with spatially separated charged and hydrophobic regions, allows them to insert themselves into the phospholipid membranes so that their hydrophobic regions are buried within the lipid membrane interior and their charged (mostly cationic) regions interact with anionic phospholipid head groups and water. Subsequently, some defensins can aggregate to form `channel-like' pores; others might bind to and cover the microbial membrane in a `carpet-like' manner. The net outcome is the disruption of membrane integrity and function, which ultimately leads to the lysis of microorganisms. Some defensins are synthesised as propeptides which may be relevant to this process. [provide by Interpro: IPR006080] |
| 生物功能 | Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. [UniProt] |
| 产品亮点 | Related products: beta Defensin4 antibodies; beta Defensin4 ELISA Kits; Related news: New MMP7 (total or active) ELISA kits are released New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 研究领域 | Immune System kit; Microbiology and Infectious Disease kit |
检测图片 (1)
ARG80902 Human BD-4 / beta Defensin-4 ELISA kit standard curve image
ARG80902 Human BD-4 / beta Defensin-4 ELISA kit results of a typical standard run with optical density reading at 450 nm.
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