Human Beta Amyloid 1-42 antibody pair (ARA834/ARA954)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Gene name: APP
- Target:pTau181
-
Brand:
CAT.NO. : ARA6878
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Size:
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Product Details
Background
The Aβ1-42 peptide is a 42-amino acid fragment cleaved from the amyloid precursor protein (APP) by secretase enzymes. It is the longer and more amyloidogenic form of the Aβ peptide, compared to the more common Aβ1-40 form. Aβ1-42 has a greater tendency to aggregate and form amyloid fibrils and plaques in the brain, which is a hallmark pathological feature of Alzheimer's disease. Increased production and accumulation of Aβ1-42 relative to Aβ1-40 is associated with genetic mutations, certain ApoE alleles, and other as-yet undiscovered factors that increase the risk of Alzheimer's disease. Measurement of the Aβ1-42 peptide in cerebrospinal fluid (CSF) is used as a biomarker for Alzheimer's disease, as decreased CSF Aβ1-42 levels indicate increased brain deposition of the peptide.The Aβ1-42/Aβ1-40 ratio in CSF is considered a more sensitive and specific marker of Alzheimer's pathology than Aβ1-42 alone.
Application
The Beta Amyloid 1-42 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| Beta Amyloid 1-42 Antibody (ARA6655) | KC-630 | Mouse IgG2a | 100μg | Liquid |
| Beta Amyloid Antibody (ARA6798) | KC-1732 | Mouse IgG2a | 100μg | Liquid |
Overview
|
Antibody Pair Specificity |
Beta Amyloid 1-42 |
|
Species Reactivity |
Human |
|
Protein Standard |
Human beta Amyloid 1-42 polypeptide |
|
Target Antigen |
Protein name: amyloid beta precursor protein; Gene name: APP; UniProt Accession: P05067; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6655 at 3 µg/mL as the capture antibody. Recommbinant Beta Amyloid 1-42 protein was used as the antigen. 1 µg/mL Beta Amyloid Antibody ARA6798 was used as the detection antibody.
Storage
Shipped at ambient temperature or with ice packs. Avoid repeated freeze-thaw cycles. Upon receipt, * 1 month when stored at 2 to 8 °C * 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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