IgG4 Rabbit Monoclonal Antibody(ARB575)

Key features and details

Target:IgG4
Host Species:rabbit monoclonal antibody
Molecular Weight:36 kDa
Purity:ProA affinity purified IgG
Species Cross - reactivity:Human
Applications:IHC - P
Swissprot ID:P01861

Brand:

CAT.NO. : ARB6867

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Size:

1mL

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Product Details

Background

IgG4 - related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4 - positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical studies in the case of IgG4 - related sclerosing disease not only exhibit significantly more than normal IgG4 - positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%).

IgG4 antibodies will dominate the IgG response in schistosomiasis, lymphatic filariasis, and in patients after allergen immunotherapy. Unlike the other IgG subclasses, IgG4 does not activate complement. A combined IgA - IgG4 deficiency has been associated with recurrent pyogenic infections.

Application

Application	Dilution Ratio
IHC	1:100-1:400

Overview

Predicted Molecular Wt	36kDa
Species Cross - reactivity	Human
Applications	IHC - P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	P01861
Subcellular location	Secreted
Recommended Method	Heat induced epitope retrieval with Tris - EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes.
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.