INI-1 Mouse Monoclonal Antibody(ARM512)
Protocol Booklet
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
- Storage:
-
Brand:
CAT.NO. : ARM6802
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose Non Fermentable) chromatin remodeling complex, which facilitates DNA-dependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumour (MRT), a tumour which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumours (sPNETs). The morphology of MRTs can often present challenges in differential diagnosis, and INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:50 - 1:200 |
Overview
|
Molecular Weight |
385 |
|
Chromosome Location |
Chromosome: 22; NC_000022.10 (24129150..24176705). Location: 22q11.23; 22q11 |
|
OMIM |
162091 |
|
3D Structure |
ModBase 3D Structure for Q12824 |
|
Clonality |
Monoclonal |
|
Isotype |
IgG2a |
|
Host |
Mouse |
|
Species Reactivity |
Human |
|
Specificity |
INI - 1 |
|
Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
|
Immunogen |
Recombinant Protein |
Data
Immunohistochemical staining of human breast carcinoma tissue sections using INI-1 Mouse Monoclonal Antibody (ARM512).
Immunohistochemical staining of human cerebral cortex tissue sections using INI-1 Mouse Monoclonal Antibody (ARM512).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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