L-Lactyl Lysine Rabbit Monoclonal Antibody(ARA874)

Key features and details

Reactivity:Human, Mouse
Application:WB, IHC, ChIP, IP
Host:Rabbit
Clonality:Monoclonal
Target:L-Lactyl Lysine

Brand:

CAT.NO. : ARA6700

US$ Please choose

Size:

50μL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones.

Application

Application	Dilution Ratio	Recommended Species
WB	1:500 - 1:1000	All Species (Predicted)
IHC-P	1:200 - 1:1000	Human, Mouse
ChIP	6 μg / 5×10⁶ cells	Human
IP	1:25 - 1:100	Human

Overview

Isotype	IgG
Conjugate	Unconjugated
Synonyms	Kla, L-la
UniProt ID	/
Immunogen	L-lactylated lysine peptides
MW (kDa)	Multiple
Specificity	Anti-L-Lactylysine Rabbit mAb detects proteins with L-lactylated lysine residues. This pan antibody recognizes L-lactylated lysine independent of its surrounding sequences.
Purity	Protein A purified
Constituents	PBS, Glycerol, BSA