MHC Ⅱ(DR α chain) Rabbit Monoclonal Antibody(ARB991)

Key features and details

Target: MHC Ⅱ(DR α chain)
Clone ID: ARB991
Host: Rabbit
Molecular Weight: 29 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: P01903

Brand:

CAT.NO. : ARB6783

RMB Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

Background

Major histocompatibility complex class II (MHC class II) molecules are heterodimeric, transmembrane glycoproteins expressed on the surface of antigen-presenting cells such as macrophages, dendritic cells, and B cells. Expression can also be induced on other cell types through interferon-γ signaling. Prior to being displayed on the cell membrane, MHC class II molecules are loaded with exogenous peptide antigens approximately 15-24 amino acids in length that were derived from endocytosed extracellular proteins digested in the lysosome. Antigen-presentation through MHC class II is required for T cell activation during the immune response to extracellular pathogens. In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA).

Application

Application	Dilution Ratio
IHC	1:100 - 1:200

Overview

Predicted Molecular Wt	29kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	P01903
Subcellular location	Membrane
Recommended method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes
Immunogen	Synthetic peptide near C-terminal residues in Human MHC Ⅱ (DR α chain) was used as an immunogen
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%