NLRP3 Guinea Pig Polyclonal Antibody
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB, Flow, ICC/IF, IHC
- Host:Guinea Pig
- Clonality:Polyclonal
- lsotype:IgG
- Target:NLRP3
-
Brand:
CAT.NO. : ARA6620
US$ Please choose
US$ Please choose
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
Application
|
Applications |
Tested Dilution |
|
Western Blot (WB) |
1:500-1:1,000 |
|
Immunohistochemistry (IHC) |
- |
|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:1,000 |
|
Immunocytochemistry (ICC/IF) |
1:100-1:500 |
|
Flow Cytometry (Flow) |
1:50-1:100 |
Overview
|
Species Reactivity |
Human, Mouse, Rat Host/Isotype |
|
Host/Isotype |
Guinea pig / IgG |
|
Expression system |
HEK293 cells |
|
Class |
Polyclonal |
|
Conjugate |
Unconjugated |
|
Immunogen |
Recombinant protein within Human NLRP3 aa 5-161 |
|
Form |
Liquid |
|
Concentration |
1 mg/mL |
|
Purification |
Protein A |
|
Storage buffer |
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
|
Contains |
0.05% sodium azide |
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
