NSE Mouse Monoclonal Antibody(ARM914)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG2a, kappa
- Target Name:NSE
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Brand:
CAT.NO. : ARM6704
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Product Details
Background
Neuron - Specific Enolase (NSE), also known as Enolase 2 (ENO2), is one of three enolase enzymes found in mammals, and acts as a phosphopyruvate hydratase. This mammalian glycolytic isoenzyme is located specifically in neurons of neuroendocrine cells, as well as tumours associated with those neurons. However, it has also been detected immunohistochemically in non - neoplastic cells of the pituitary, peptide - secreting tissues, pinealocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. NSE is a useful marker for identifying normal striated muscle, hepatocytes, and peripheral nerves. Anti - NSE may detect for neuroendocrine differentiation, only when used in a panel of antibodies including more specific markers such as synaptophysin, chromogranin, and neurofilament.
Application
IHC: 1:50-1:200
Overview
|
Molecular Weight |
47,269 Da |
|
Chromosome Location |
Chromosome: 12; NC_000012.11 (7023614..7032859). Location: 12p13 |
|
OMIM |
131360 |
|
3D Structure |
ModBase 3D Structure for P09104 |
|
Clonality |
Monoclonal |
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Isotype |
IgG2a, kappa |
|
Host |
Mouse |
|
Species Reactivity |
Human |
|
Specificity |
NSE |
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Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
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Immunogen |
Recombinant Protein |
Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Carcinoid Tumour sections labeling NSE with ARM914
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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