p63 Rabbit Monoclonal Antibody(ARA944)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:p63
-
Brand:
CAT.NO. : ARA6785
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function. While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors. Research investigators frequently observe amplification of the p63 gene in squamous cell carcinomas of the lung, head and neck. The p63 gene contains an alternative transcription initiation site that yields a 40 kDa δNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the α, β, and γ isoforms.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:800-1:2,000 |
Overview
|
Antibody Type |
Recombinant Rabbit Monoclonal Antibody |
|
Immunogen |
Recombinant protein within human p63 aa 1 - 250 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IF-Cell, IF-Tissue, IHC-P, FC |
|
Molecular Weight |
Predicted band size: 77 kDa |
|
Positive Control |
A431 cell lysate, MCF7 cell lysate, HaCaT cell lysate, Mouse skin tissue lysate, Rat skin tissue lysate, A431, human skin tissue, human breast tissue, human esophagus tissue, mouse esophagus tissue, rat esophagus tissue |
|
Conjugation |
unconjugated |
|
Clone Number |
SC06-31 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human skin tissue using p63 Rabbit Monoclonal Antibody(ARA944)
Immunohistochemical staining of human breast tissue using p63 Rabbit Monoclonal Antibody(ARA944)
Immunohistochemical staining of human esophagus tissue using p63 Rabbit Monoclonal Antibody(ARA944)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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