p63 Rabbit Monoclonal Antibody(ARB831)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6621
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
p63 is a transcription factor related to the tumor suppressor gene p53 and play a critical role in the development of stratified epithelia by maintaining basal cell regenerative capacity and perhaps by playing a role in mediating ectodermal-mesenchymal interactions.
In normal tissues, p63 expression is presented in the basal cells of stratified epithelia such as skin, ectocervix, esophagus, urothelium, and bronchi. p63 is also found in basal cells of glandular tissue such as prostate and breast and in lymphoid tissue. In tumor tissues, the p63 gene is amplified and the protein is overexpressed in primary lung and head and neck squamous cell carcinomas. Squamous cell carcinomas of the larynx, esophagus, skin, and cervix also express p63. p63 expression has also been documented in basal cell carcinomas of skin. However, some studies also show that p63 expressed in a subset of adenocarcinomas and large cell carcinomas of lung.In diagnostic pathology practice, p63 has been studied as a marker of basal cells to help in the diagnosis of ductal carcinoma in situ of the breast versus invasive carcinoma in fine-needle aspirates. Similarly, p63 has been tested as a marker to identify basal cells in the diagnostic work-up for prostatic cancer. Recently, some studies have suggested that p63 in combination with other markers may be used to help in differentiating squamous cell carcinomas from other tumor types in cases difficult to diagnose histologically.
In normal tissues, p63 expression is presented in the basal cells of stratified epithelia such as skin, ectocervix, esophagus, urothelium, and bronchi. p63 is also found in basal cells of glandular tissue such as prostate and breast and in lymphoid tissue. In tumor tissues, the p63 gene is amplified and the protein is overexpressed in primary lung and head and neck squamous cell carcinomas. Squamous cell carcinomas of the larynx, esophagus, skin, and cervix also express p63. p63 expression has also been documented in basal cell carcinomas of skin. However, some studies also show that p63 expressed in a subset of adenocarcinomas and large cell carcinomas of lung.In diagnostic pathology practice, p63 has been studied as a marker of basal cells to help in the diagnosis of ductal carcinoma in situ of the breast versus invasive carcinoma in fine-needle aspirates. Similarly, p63 has been tested as a marker to identify basal cells in the diagnostic work-up for prostatic cancer. Recently, some studies have suggested that p63 in combination with other markers may be used to help in differentiating squamous cell carcinomas from other tumor types in cases difficult to diagnose histologically.
Overview
| Target | p63 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 77 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | Q9H3D4 |
| Immunogen | Synthetic peptide corresponding to p63 residues within aa580-680 of p63 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nucleus |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human prostatic tissue sections was performed using p63 Rabbit Monoclonal Antibody (ARB831).
Immunohistochemical staining of human esophageal tissue sections was performed using p63 Rabbit Monoclonal Antibody (ARB831).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
