PRPS2 Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB
- Host:Rabbit
- Clonality:Polyclonal
- Target:PRPS2
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Brand:
CAT.NO. : ARA6873
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Product Details
Background
The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:1000 |
Overview
|
Immunogen |
Recombinant fusion protein of human PRPS2. The exact sequence is proprietary. |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography. |
|
Clonality |
Polyclonal |
|
Product Form |
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
|
Gene Name |
PRPS2 |
|
Alternative Names |
Ribose-phosphate pyrophosphokinase 2; PRPRibP; Phosphoribosyl pyrophosphate synthase II; PRS-II |
|
Human Gene ID |
5634 |
|
Mouse Gene ID |
110639 |
|
Rat Gene ID |
24689 |
|
Human Protein ID |
P11908 |
|
Mouse Protein ID |
Q9CS42 |
|
Rat Protein ID |
P09330 |
Data
Western blot analysis of PRPS2 expression in MCF7 (A), mouse brain (B), rat liver (C) whole cell lysates. (Predicted band size: 34; 35 kD; Observed band size: 35 kD)
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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