PRSS2 Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB, IHC, IF/ICC
- Host:Rabbit
- Clonality:Polyclonal
- lsotype:IgG
- Target:PRSS2
-
Brand:
CAT.NO. : ARA6894
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Product Details
Background
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:1,000 |
|
IHC |
1:200 - 1:1,000 |
|
IF/ICC |
1:50 - 1:200 |
Overview
|
Product Name |
PRSS2 Rabbit Polyclonal Antibody |
|
Antibody Type |
Rabbit Polyclonal Antibody |
|
Immunogen |
Recombinant protein within human PRSS2 aa 1-120. |
|
Species Reactivity |
Human, Rat, Mouse |
|
Validated Applications |
WB, IHC, IF/ICC |
|
Molecular Weight |
26 kDa |
|
Positive Control |
Human small intestine tissue lysates, rat pancreas tissue, human pancreas tissue, mouse pancreas tissue, SH-SY5Y. |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Storage Buffer |
1×TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
|
Isotype |
IgG |
|
Purification Method |
Immunogen affinity purified. |
Data
Western blot analysis of PRSS2 on human small intestine tissue lysates.
Immunohistochemical analysis of paraffin-embedded rat pancreas tissue using PRSS2 Rabbit Polyclonal Antibody.
IF/ICC staining of PRSS2 in SH-SY5Y cells (green).
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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