pTau217 Mouse Monoclonal Antibody(ARA974)
Key features and details
- Reactivity:Human
- Application:ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:pTau217
-
Brand:
CAT.NO. : ARA6840
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Product Details
Background
Plasma p-tau217 is a biomarker associated with Alzheimer's disease (AD) pathology. Research has shown that plasma p-tau217 is a sensitive marker of the clinical manifestation and progression of AD, including amyloid accumulation, tau burden, brain atrophy, and physical degradation. It has been found to be a potential non-invasive biomarker of AD, with high diagnostic accuracy in differentiating AD from other neurodegenerative diseases. Plasma p-tau217 has also been associated with longitudinal increases in Aβ PET uptake and cognitive decline in Aβ-positive clinically unimpaired individuals. Additionally, higher baseline p-tau217 levels have been linked to greater future tau PET pathology burden and worse future memory performance. These findings suggest that plasma p-tau217 could serve as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials.
Application
|
Application |
Dilution Ratio |
|
ELISA |
1:1,500- 1:2,000 |
Overview
|
Antibody specificity |
pTau217 |
|
Species reactivity |
Human |
|
Clonality |
Monoclonal |
|
Host / isotype |
Mouse / IgG1 |
|
Immunogen |
Synthetic peptide within aa200-250 of Tau. The exact peptide sequence is proprietary information. |
|
Cross reactivity |
Not tested |
|
Recombinant |
Not recombinant |
|
Purification |
Protein A purification |
|
Form |
Liquid |
|
Conjugation |
Unconjugated |
Data
Sandwich ELISA
analysis of pTau217 by ARA6840 & ARA6843. Microtiter plates were coated with KAA338_16C8 as the capture antibody. Recommbinant pTau217 protein (AXP6612) was applied as the antigen. Peroxidase conjugated pTau217 Antibody (ARA6843) served as the detection antibody.
Result: ARA6840 and ARA6843 can be used as a matched antibody pair to detect and quantify the concentration of pTau217.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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