Rat Arg1(Arginase-1) ELISA Kit

Key features and details

Specificity: 1.5ng/ml
Detection Range: 2.5-160ng/ml
Sample Types: Plasma, tissue homogenates and other biological fluids in vitro
Species:Rat
Detection Method: Sandwich ELISA
Target:Arginase-1 (Arg1)

Brand:

CAT.NO. : ARE6626

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Size:

96T

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Product Details

Background

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Overview

Name	Rat Arg1(Arginase-1) ELISA Kit
Synonyms	Arg1\|arginase\| liver\|arginase-1\|Liver-type arginase\|Type I arginase ELISA Kit
Species Reactivity	Rat
Size	96T
UNIPROT ID	P07824
Application	The Arginase 1 (ARG1) ELISA kit can be used to quantitatively determine the concentration of Arginase 1 (ARG1) in plasma, tissue homogenates and other biological fluids in vitro.
Detection Method	Sandwich ELISA
Detection Range	2.5 - 160ng/ml
Sensitivity	< 1.5ng/ml