Recombinant Human Beta Amyloid Protein
Key features and details
- Product Name:
- Expression Systems:
- Species:
- Formulation:
-
Brand:
CAT.NO. : AXP6620
RMB Please choose
RMB Please choose
Size:
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Product Details
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Overview
|
Gene name |
APP |
|
Organism |
Homo sapiens (Human) |
|
Product name |
Human beta Amyloid 1-42 polypeptide |
|
Predicted molecular mass |
4.5 kDa |
|
Form |
Lyophilized powder |
Data
The purified product was run on 15% SDS-PAGE at reducing conditions. The gel was stained with Coomassie brilliant blue and destained.  Note: The protein has a predicted molecular weight of 67.5 but miigrates at 100 in SDS-PAGE under reducing conditions, likely dueto glycosylation.
Storage
Shipped at ambient temperature or with ice packs.
Upon receipt,
* Lyophilized form: 12 months when stored at -20 °C or below, protected from light and moisture.
* After reconstitution: aliquot to avoid repeated freeze-thaw cycles:
• 2 days when stored at 2 to 8 °C.
• 3 months when stored at -20 °C or below.
Upon receipt,
* Lyophilized form: 12 months when stored at -20 °C or below, protected from light and moisture.
* After reconstitution: aliquot to avoid repeated freeze-thaw cycles:
• 2 days when stored at 2 to 8 °C.
• 3 months when stored at -20 °C or below.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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