Recombinant Human Glial Cell Line-derived Neurotrophic Factor
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CAT.NO. : ARP6657
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Background
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinacocytes and skeletal muscle cells. Rat and human mature GDNF shows 93% sequence identity and have species cross-reactivity. The calculated molecular weight of Recombinant Human GDNF is 30.1kDa.
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