Recombinant Murine Granulocyte-Macrophage Colony Stimulating Factor
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CAT.NO. : ARP6678
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Product Details
Background
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is secreted by a number of different cell types in response to cytokine or immune and inflammatory stimulation. It was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors and has functions of stimulates the growth and differentiation of hematopoietic precursor cells from various lineages. GM-CSF has also been reported to have a functional role on non-hematopoietic cells and can induce human endothelial cells to migrate and proliferate. Additionally, it can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. Mouse GM-CSF shares 54% sequences identity with human GM-CSF, but has no biological effects across species. GM-CSF is used as a medication to stimulate the production of white blood cells following chemotherapy and has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. Recombinant Murine GM-CSF is a 14.1kDa globular protein consisting of 124 amino acid residues.
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