ROR gamma T Rabbit Monoclonal Antibody(ARB538)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6830
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Size:
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Product Details
Background
Retina-associated orphan receptors (RORs) contains three subtypes: RORα, RORβ, and RORγ. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, RORα and RORγ play an important role in mediating Th17 cell differentiation. RORγ can be divided into RORγ1 and RORγ2 (RORγ T), which show different tissue specificity.
ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ "double positive" thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTI) cells of lymphoid organs.
At present, RORγ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORγ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.
ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ "double positive" thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTI) cells of lymphoid organs.
At present, RORγ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORγ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
55kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P51449-2 |
|
Subcellular location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Recombinant protein fragment of ROR gamma T was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human tonsil tissue using ROR gamma T Rabbit Monoclonal Antibody(ARB538)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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