Somatostatin receptor 2 Rabbit Monoclonal Antibody(ARA893)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:Somatostatin receptor 2
-
Brand:
CAT.NO. : ARA6720
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100-1:200 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within human Somatostatin Receptor 2 aa 320-369 / 369 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IHC-P, IF-Tissue, IHC-Fr |
|
Molecular Weight |
Predicted band size: 41 kDa |
|
Positive Control |
SH-SY5Y cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, mouse brain tissue, human brain tissue, rat brain tissue |
|
Conjugation |
unconjugated |
|
RRID |
AB_3070337 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded human brain tissue with Somatostatin receptor 2 Rabbit Monoclonal Antibody(ARA893)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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