Thymidine Phosphorylase Mouse Monoclonal Antibody(ARA840)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB, IHC
- Host: Mouse
- Clonality:Monoclonal
- Target:Thymidine Phosphorylase
-
Brand:
CAT.NO. : ARA6648
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Platelet-derived endothelial cell growth factor (PD-ECGF), which is alternatively designated thymidine phosphorylase or gliostatin, is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. Biologically active PD-ECGF is a functional dimer that consists of two single polypeptide chains that are expressed in platelets, placenta, foreskin fibroblasts and various squamous cell carcinomas, and they are slowly secreted from the cells. In addition, PD-ECGF is overexpressed in tumor and lesional psoriatic skin and lesional epidermis, indicating that it may play a role in the pathophysiology of psoriasis. Serine residues of PD-ECGF are frequently associated with nucleotide triphosphates, including ATP. In an ATP dependent manner, PD-ECGF is also able to catalyze the reversible phosphorolysis of thymidine to thymine, as it contains thymidine phosphorylase activities.
Application
|
Application |
Dilution Ratio |
|
WB |
1:800-1:1,000 |
|
IHC-P |
1:3,000-1:10,000 |
Overview
|
Product Name |
Thymidine Phosphorylase Recombinant Mouse Monoclonal Antibody (ARA840) |
|
Antibody Type |
Recombinant Mouse Monoclonal Antibody |
|
Immunogen |
Recombinant protein within Human Thymidine Phosphorylase aa 19-239 /482. |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IHC-P |
|
Molecular Weight |
Predicted band size: 50 kDa |
|
Positive Control |
THP-1 cell lysate, A549 cell lysate, A31 cell lysate, HeLa cell lysate, mouse spleen tissue, rat spleen tissue. |
|
Conjugation |
unconjugated |
Data
Immunohistochemical analysis of paraffin-embedded rat spleen tissue with Thymidine Phosphorylase Mouse Monoclonal Antibody(ARA840)
Immunohistochemical analysis of paraffin-embedded mouse spleen tissue with Thymidine Phosphorylase Mouse Monoclonal Antibody(ARA840)
Western blot analysis of Thymidine Phosphorylase on different lysates with Thymidine Phosphorylase Mouse Monoclonal Antibody(ARA840) at 1/1,000 dilution. Lane 1: THP-1 cell lysate Lane 2: A549 cell lysate Lane 3: A431 cell lysate Lane 4: HeLa cell lysate Lysates/proteins at 20 µg/Lane. Predicted band size: 50 kDa Observed band size: 50 kDa Exposure time: 25 seconds; 4-20% SDS-PAGE gel.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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