TRIM29 Rabbit Monoclonal Antibody(ARA963)

Key features and details

Reactivity:Human
Application:WB, IHC-P
Host:Rabbit
Clonality:Monoclonal
lsotype:IgG
Target:TRIM29

Brand:

CAT.NO. : ARA6816

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Size:

1mL

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Product Details

Background

Tripartite motif-containing protein 29 (TRIM29, ATDC) was isolated as a candidate gene by its ability to complement the radiosensitivity defect of an ataxia-telangiectasia (AT) cell line. This putative transcription regulator belongs to the TRIM (tripartite motif) protein family that is characterized by highly conserved amino-terminal RING finger, B-box, and coiled-coil domains. The TRIM29 protein binds and sequesters cytosolic p53, repressing expression of p53 target genes including p21 and Noxa by preventing p53 from entering the nucleus. Expression of TRIM29 inhibits p53 function and results in increased cell proliferation. TRIM29 enhances tumor growth and metastasis in vivo and high TRIM29 levels are seen in most invasive pancreatic cancers. The oncogenic effect of TRIM29 appears to require β-catenin as expression of both proteins is elevated in pancreatic cancer cell lines and tissues.

Application

Application	Dilution Ratio
IHC-P	1:500 - 1:2000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within human TRIM29 aa 1-588 / 588.
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IHC-P, IF-Cell, FC
Molecular Weight	Predicted band size: 66 kDa
Positive Control	A431 cell lysate, SiHa cell lysate, SW1900 cell lysate, HT-29 cell lysate, A431, human prostate tissue, human skin tissue, mouse skin tissue, rat skin tissue.
Conjugation	unconjugated
Form	Liquid
Storage Buffer	PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified