ZAP-70 Rabbit Monoclonal Antibody(ARB859)
Key features and details
- Target:ZAP - 70
- Host Species:rabbit monoclonal antibody
- Molecular Weight:70 kDa
- Purity:ProA affinity purified IgG
- Species Cross - reactivity:Human
- Applications:IHC - P
- Swissprot ID:P43403
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Brand:
CAT.NO. : ARB6651
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Product Details
Background
Zeta - associated protein - 70 (ZAP - 70) is a member of the Syk family of tyrosine kinases, a group of proteins that attach to the zeta chain components of T - cell receptors to signal downstream events involved in the regulation of cell function, proliferation, and death. Research suggests that the ZAP - 70 protein may also play an important role in natural killer (NK) cell activation and early B - cell development; however, it is not expressed in most normal B - cells. Expression of ZAP - 70 has been reported in various lymphomas, including mantle cell lymphoma, small lymphocytic lymphoma and marginal zone lymphoma. During thymocyte development, ZAP - 70 promotes survival and cell - cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP - 70 - dependent signaling pathway may also contribute to primary B - cells formation and activation through B - cell receptor (BCR).
Overview
| Target | ZAP-70 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 70 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P43403 |
| Immunogen | Synthetic peptide corresponding to residues within aa200-350 of ZAP-70 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nuclear, Cytoplasmic |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Data
Immunohistochemistry (Formalin/PFA - fixed, paraffin - embedded sections) analysis of tonsil tissue labeling ZAP - 70 with ARA859. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9.0.
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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