anti-CC2D1A antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57331
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CC2D1A |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CC2D1A |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human CC2D1A. |
| 偶联标记 | Un-conjugated |
| 別名 | MRT3; Five prime repressor element under dual repression-binding protein 1; Freud-1/Aki1; FREUD-1; Akt kinase-interacting protein 1; Putative NF-kappa-B-activating protein 023N; Freud-1; FRE under dual repression-binding protein 1; Coiled-coil and C2 domain-containing protein 1A |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SKOV3 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CC2D1A |
| 全名 | coiled-coil and C2 domain containing 1A |
| 背景介绍 | This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009] |
| 生物功能 | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. [UniProt] |
| 预测分子量 | 104 kDa |
| 翻译后修饰 | Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21. |
检测图片 (1)
ARG57331 anti-CC2D1A antibody WB image
Western blot: SKOV3 cell lysate stained with ARG57331 anti-CC2D1A antibody.
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