anti-CD108 antibody [MEM-150] (FITC)

产品描述: FITC-conjugated Mouse Monoclonal antibody [MEM-150] recognizes CD108
反应物种: Hu
应用: FACS
特异性: The clone MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.HLDA V; WS Code AS S017HLDA V; WS Code BP BP347 HLDA VI; WS Code BP 401 HLDA VI; WS Code BP 475 HLDA VI; WS Code NL N-L156 HLDA VI; WS Code P PR-65
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-150
同位型: IgM
靶点名称: CD108

CAT.NO. : ARG65488

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Size:

50 tests

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	FITC-conjugated Mouse Monoclonal antibody [MEM-150] recognizes CD108
反应物种	Hu
应用	FACS
特异性	The clone MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes. HLDA V; WS Code AS S017 HLDA V; WS Code BP BP347 HLDA VI; WS Code BP 401 HLDA VI; WS Code BP 475 HLDA VI; WS Code NL N-L156 HLDA VI; WS Code P PR-65
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-150
同位型	IgM
靶点名称	CD108
抗原物种	Human
抗原	HPB-ALL human T cell line
偶联标记	FITC
別名	H-Sema-L; Sema L; Semaphorin-7A; Sema K1; CDw108; SEMAK1; CD antigen CD108; CD108; John-Milton-Hargen human blood group Ag; Semaphorin-L; Semaphorin-K1; JMH; H-SEMA-K1; SEMAL; JMH blood group antigen

应用说明

应用建议

应用	推荐稀释比
FACS	20 µl / 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化说明	The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
缓冲液	TBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂	15 mM Sodium azide
稳定剂	0.2% (w/v) high-grade protease free BSA
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8482 Human SEMA7A Swiss-port # O75326 Human Semaphorin-7A
基因名称	SEMA7A
全名	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
背景介绍	CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors – plexin C1 and beta1 integrins.
生物功能	Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. [UniProt]
研究领域	Cell Biology and Cellular Response antibody; Immune System antibody; Neuroscience antibody
预测分子量	75 kDa

检测图片 (1)

ARG65488 anti-CD108 antibody [MEM-150] (FITC) FACS image
Flow Cytometry: HPB-ALL human peripheral blood T cell leukemia cell line stained with ARG65488 anti-CD108 antibody [MEM-150] (FITC).
Total viable cells were used for analysis.

参考文献

克隆号文献

Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling.

WB, ICC/IF / Mouse

Sultana H et al.
J Immunol., (2012)