anti-CD173 / Blood group H2 antigen antibody [BRIC231]
![anti-CD173 / Blood group H2 antigen antibody [BRIC231]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
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CAT.NO. : ARG22731
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [BRIC231] recognizes CD173 / Blood group H2 antigen. |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | FACS |
| 特异性 | This antibody recognizes Human type 2 H blood group antigen, also known as CD173 / Blood group H2 antigen. Active H substances in man, are expressed by many cells and tissues and also by erythrocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BRIC231 |
| 同位型 | IgG1 |
| 靶点名称 | CD173 / Blood group H2 antigen |
| 抗原物种 | Human |
| 抗原 | Human erythroleukemic cell line (HEL) established from a 30 year old patient with relapsed erythroleukemia following treatment for Hodgkin lymphoma. |
| 偶联标记 | Un-conjugated |
| 別名 | Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Fucosylglycoprotein 3-alpha-galactosyltransferase; GTB; Histo-blood group A transferase; NAGAT; A3GALT1; Histo-blood group ABO system transferase; EC 2.4.1.40; A transferase; Histo-blood group B transferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; A3GALNT; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; B transferase; EC 2.4.1.37 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Unpurified. |
| 缓冲液 | TRIS buffered glycine and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P16442 Human Histo-blood group ABO system transferase |
|---|---|
| 基因名称 | ABO |
| 全名 | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) |
| 背景介绍 | This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. [UniProt] |
| 细胞定位 | Cell surface |
| 翻译后修饰 | The soluble form derives from the membrane form by proteolytic processing. |
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