anti-CD206 / MMR antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CD206 / MMR
  • 反应物种: Hu, Ms, Rat, Pig
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CD206 / MMR
  • 抗原物种: Human
  • 抗原: KLH-conjugated synthetic peptide from Human CD206 / MMR.
  • Brand:
CAT.NO. : ARG22372
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CD206 / MMR
反应物种Hu, Ms, Rat, Pig
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CD206 / MMR
抗原物种Human
抗原KLH-conjugated synthetic peptide from Human CD206 / MMR.
偶联标记Un-conjugated
別名CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1
应用说明
应用建议
应用推荐稀释比
ICC/IF1:400
IHC-P1:100 - 1:500
WB1:300 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS and 0.02% Sodium azide.
抗菌剂0.02% Sodium azide
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 17533 Mouse MRC1

GeneID: 4360 Human MRC1

Swiss-port # P22897 Human Macrophage mannose receptor 1

Swiss-port # Q61830 Mouse Macrophage mannose receptor 1

基因名称MRC1
全名mannose receptor, C type 1
背景介绍The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
生物功能CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
产品亮点Related products:
CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
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研究领域Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
预测分子量166 kDa
检测图片 (10)
  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat colon tissue stained with ARG22372 anti-CD206 / MMR antibody at 5 µg/ml dilution.

  • ARG22372 anti-CD206 / MMR antibody WB image

    Western blot: 1) Rat brain, 2) Rat kidney, and 3) Mouse brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:500 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat skin tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat skin tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Pig kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Pig heart tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

参考文献

Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN

WB / Human

Zhong-Zhao Zhang et al.
Kaohsiung J Med Sci,  (2022)

publication_link

 

hr_line

Abrogation of Toll like receptor 4 (TLR4) mitigates obesity-induced oxidative stress, proinflammation, and insulin resistance through metabolic reprogramming of mitochondria in adipose tissue.

IHC-P / Mouse

Lin Hung-Yu et al.
Antioxid Redox Signal.,  (2020)

publication_link

 

hr_line

Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells.

ICC/IF / Human

Yin Xiteng et al.
Cell Oncol (Dordr).,  (2019)

publication_link

 

hr_line
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