anti-CD46 antibody [169-1-E4.3]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [169-1-E4.3] recognizes CD46
  • 反应物种: Hu
  • 不反应物种: Hrs
  • 应用: FACS, ICC/IF
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 169-1-E4.3
  • 同位型: IgG2a, kappa
  • 靶点名称: CD46
  • Brand:
CAT.NO. : ARG56050
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Product Details
概述
产品描述Mouse Monoclonal antibody [169-1-E4.3] recognizes CD46
反应物种Hu
不反应物种Hrs
应用FACS, ICC/IF
宿主Mouse
克隆Monoclonal
克隆号169-1-E4.3
同位型IgG2a, kappa
靶点名称CD46
抗原物种Human
抗原Stimulated Human leukocytes.
偶联标记Un-conjugated
別名MIC10; TLX; CD antigen CD46; Trophoblast leukocyte common antigen; AHUS2; TRA2.10; Membrane cofactor protein; MCP
应用说明
应用建议
应用推荐稀释比
FACS1 - 2 µg/10^6 cells
ICC/IF1 - 2 µg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA
抗菌剂0.05% Sodium azide
稳定剂0.1 mg/ml BSA
浓度0.2 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 4179 Human CD46

Swiss-port # P15529 Human Membrane cofactor protein

基因名称CD46
全名CD46 molecule, complement regulatory protein
背景介绍The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
生物功能Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. [UniProt]
细胞定位Cell surface
预测分子量44 kDa
翻译后修饰N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding.
In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.
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