anti-Cytochrome C antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG20006
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Cytochrome C |
|---|---|
| 反应物种 | Hu, Ms, Rat, Bov, Chk, Dog |
| 应用 | IP, WB |
| 特异性 | The cytochrome c antibody detects the 12.6 kDa cytochrome c from human, mouse, and rat samples. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cytochrome C |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide corresponding to residues surrounding amino acid 70 of rat cytochrome C |
| 偶联标记 | Un-conjugated |
| 別名 | CYCTA |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat cell lysate, NIH3T3 cell lysate, and rat kidney tissue lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified Antibody |
| 缓冲液 | PBS (pH 7.2), 30% Glycerol, 0.5% BSA and 0.01% Thimerosal |
| 抗菌剂 | 0.01% Thimerosal |
| 稳定剂 | 30% Glycerol, 0.5% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | Cyct |
|---|---|
| 全名 | cytochrome c, testis |
| 背景介绍 | Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases |
| 生物功能 | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30106 Mitochondria/Caspase Dependant Apoptosis Marker Antibody Duo (Caspase9, Cytochrome c) ARG30110 Mitochondria/Caspase dependant Apoptosis Antibody Panel (Caspase3, Caspase9, Cytochrome c, PARP) (WB) Related products: Cytochrome C antibodies; Cytochrome C Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related poster download: The Structure & Functions of Mitochondria.pdf |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody; Mitochondria/Caspase Dependant Apoptosis Marker antibody; Mitochondrial Marker antibody; Cytochrome-C fractionation Study antibody |
| 预测分子量 | 12 kDa |
检测图片 (1)
ARG20006 anti-Cytochrome C antibody WB image
Western blot: 20 µg of Mouse testis lysate stained with ARG20006 anti-Cytochrome C antibody at 2 µg/ml dilution.
参考文献
Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs.
scPISA / Human
Probing apoptosis signaling proteins in single living cells for precision efficacy evaluation of anti-cancer drugs.
/ Human
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