anti-HPK1 / MAP4K1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG63454
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes HPK1 / MAP4K1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Pig |
| 应用 | IHC-P, WB |
| 特异性 | This antibody is expected to recognise isoform 1 (NP_001036065.1) and isoform 2 (NP_009112.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HPK1 / MAP4K1 |
| 抗原物种 | Human |
| 抗原 | DVVDPDIFNRDPR-C |
| 偶联标记 | Un-conjugated |
| 別名 | MAPK/ERK kinase kinase kinase 1; HPK1; Mitogen-activated protein kinase kinase kinase kinase 1; MEKKK 1; EC 2.7.11.1; Hematopoietic progenitor kinase; MEK kinase kinase 1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q92918 Human Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|---|
| 基因名称 | MAP4K1 |
| 全名 | mitogen-activated protein kinase kinase kinase kinase 1 |
| 生物功能 | Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 91 kDa |
| 翻译后修饰 | Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. |
检测图片 (2)
ARG63454 anti-HPK1 / MAP4K1 antibody WB image
Western Blot: Jurkat lysate (RIPA buffer, 35 µg total protein per lane) stained with ARG63454 anti-HPK1 / MAP4K1 antibody at 0.5 µg/ml dilution.
ARG63454 anti-HPK1 / MAP4K1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thymus tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG63454 anti-HPK1 / MAP4K1 antibody at 2.5 µg/ml dilution followed by AP-staining.
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