anti-Hsp 27 antibody [B317]

CAT.NO. : ARG62506

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Size:

100 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [B317] recognizes Hsp 27
反应物种	Hu
应用	IHC-Fr, IHC-P, WB
宿主	Mouse
克隆	Monoclonal
克隆号	B317
同位型	IgG1, kappa
靶点名称	Hsp 27
抗原物种	Human
抗原	Partially purified HSP27 derived from MCF-7 cytosol.
偶联标记	Un-conjugated
別名	HSP 27; Heat shock 27 kDa protein; HMN2B; HS.76067; SRP27; HEL-S-102; HspB1; CMT2F; 28 kDa heat shock protein; HSP27; Heat shock protein beta-1; Hsp25; Estrogen-regulated 24 kDa protein; Stress-responsive protein 27; HSP28

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Breast Carcinoma

属性

形式	Liquid
纯化	Purified Antibody
缓冲液	1X PBS and 0.1% Sodium azide
抗菌剂	0.1% Sodium azide
浓度	0.2 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3315 Human HSPB1 Swiss-port # P04792 Human Heat shock protein beta-1
基因名称	HSPB1
全名	heat shock 27kDa protein 1
背景介绍	The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
生物功能	Involved in stress resistance and actin organization. [UniProt]
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
预测分子量	23 kDa
翻译后修饰	Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925).