anti-MOCS3 antibody
Key features and details
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- 反应物种:
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- 抗原:
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Brand:
CAT.NO. : ARG59958
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MOCS3 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MOCS3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 271-460 of Human MOCS3 (NP_055299.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Sulfur carrier protein MOCS2A adenylyltransferase; Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; EC 2.8.1.11; UBA4; EC 2.7.7.80; MPT synthase sulfurylase; Molybdopterin synthase sulfurylase; Sulfur carrier protein MOCS2A sulfurtransferase; Molybdenum cofactor synthesis protein 3; Sulfurtransferase MOCS3 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse ovary and HepG2 | ||||
| 实际分子量 | 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # A2BDX3 Mouse Adenylyltransferase and sulfurtransferase MOCS3 Swiss-port # O95396 Human Adenylyltransferase and sulfurtransferase MOCS3 |
|---|---|
| 基因名称 | MOCS3 |
| 全名 | molybdenum cofactor synthesis 3 |
| 背景介绍 | Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012] |
| 生物功能 | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 50 kDa |
检测图片 (1)
ARG59958 anti-MOCS3 antibody WB image
Western blot: 25 µg of Mouse ovary and HepG2 cell lysates stained with ARG59958 anti-MOCS3 antibody at 1:1000 dilution.
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