anti-MYLIP / IDOL antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG42128
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MYLIP / IDOL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MYLIP / IDOL |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 111-139 of Human MYLIP / IDOL. |
| 偶联标记 | Un-conjugated |
| 別名 | Inducible degrader of the LDL-receptor; EC 6.3.2.-; Myosin regulatory light chain interacting protein; E3 ubiquitin-protein ligase MYLIP; IDOL; MIR; Idol |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Rat brain | ||||||||
| 实际分子量 | ~ 48 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYLIP |
| 全名 | myosin regulatory light chain interacting protein |
| 背景介绍 | The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008] |
| 生物功能 | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. [UniProt] |
| 细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein. [UniProt] |
| 预测分子量 | 50 kDa |
| 翻译后修饰 | Autoubiquitinated. [UniProt] |
检测图片 (3)
ARG42128 anti-MYLIP / IDOL antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human brain tissue stained with ARG42128 anti-MYLIP / IDOL antibody.
ARG42128 anti-MYLIP / IDOL antibody WB image
Western blot: 20 µg of Rat brain lysate stained with ARG42128 anti-MYLIP / IDOL antibody 1:2000 dilution.
ARG42128 anti-MYLIP / IDOL antibody FACS image
Flow Cytometry: MCF7 cells stained with ARG42128 anti-MYLIP / IDOL antibody (right histogram) or without primary antibody as control (left histogram), followed by incubation with FITC labelled secondary antibody.
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