anti-N Cadherin antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes N Cadherin
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: N Cadherin
  • 抗原物种: Human
  • 抗原: Synthetic peptide corresponding to aa. 811-824 of Human N Cadherin.
  • Brand:
CAT.NO. : ARG59251
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes N Cadherin
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称N Cadherin
抗原物种Human
抗原Synthetic peptide corresponding to aa. 811-824 of Human N Cadherin.
偶联标记Un-conjugated
別名Neural cadherin; N-cadherin; CDw325; CDHN; CD antigen CD325; NCAD; Cadherin-2; CD325
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Mouse brain
实际分子量~ 135 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1000 Human CDH2

GeneID: 12558 Mouse CDH2

GeneID: 83501 Rat CDH2

基因名称CDH2
全名cadherin 2, type 1, N-cadherin (neuronal)
背景介绍N Cadherin is a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
生物功能N Cadherin is a calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [UniProt]
细胞定位Cell membrane, Single-pass type I membrane protein. [UniProt]
研究领域EMT Study antibody; Mesenchymal Markers antibody
预测分子量100 kDa
翻译后修饰Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).

May be phosphorylated by OBSCN. [UniProt]
检测图片 (2)
  • ARG59251 anti-N Cadherin antibody WB image

    Western blot: 20 µg of Mouse brain lysate stained with ARG59251 anti-N Cadherin antibody at 1:1000 dilution.

  • ARG59251 anti-N Cadherin antibody IP image

    Immunoprecipitation: 200 µg extracts of HeLa cells were immunoprecipitated and stained with ARG59251 anti-N Cadherin antibody at 1:1000 dilution.

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